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Cyclosporin A by Tandem Mass Spectrometry.

Mnemonic:    [CYCLO]
Name:    Cyclosporin A by Tandem Mass Spectrometry.
Specimen:    1 mL EDTA Lavender top tube. Pre-dose (trough) levels should be drawn.

Unacceptable conditions:
-Clotted samples
-Samples left at ambient temperature >24 hours
Minimum Spec:    0.2 5 Ml
Transport Temp:    Refrigerated
Spec Stability:    Stable up to 2 weeks refrigerated.
Ref Lab/Code:    ARUP 0070035
  Method:    Fluorescence Polarization Immunoassay (FPIA)
Note:    Cyclosporine (SandimmuneŽ) whole blood concentrations can be measured by either chromatographic or immunoassay methodologies. These two methodologies are not directly interchangeable, and the measured cyclosporine whole blood concentration depends upon the type of assay used. Reference ranges may vary according to the specific immunoassay or LC/MS/MS test used. Generally, immunoassays have been reported to have a positive bias relative to the reference assay, HPLC with detection by tandem mass spectrometry (LC/MS/MS).