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PCA3 (Prostate Cancer Biomarker)

Mnemonic:    [PCA3]
Name:    PCA3 (Prostate Cancer Biomarker)
Specimen:     Patient Preparation: Collection must follow Digital Rectal Exam (DRE).

Collect: 20-30 mL first catch urine following DRE in preservative-free urine collection cup.

Specimen Preparation: Invert urine container 5 times to mix. Transfer 2.5 mL urine ASAP or within 4 hours of collection into two (2) Progensa PCA3 Urine Specimen Transport Tubes (ARUP Supply #45682) available online through eSupply using ARUP Connect or contact ARUP Client Services at (800) 522-2787. (Min: 2.5 mL per tube) Liquid level must be between black lines on transport tubes. Cap transport tubes and invert 5 times to mix.
Transport Temp:    FREEZE
Spec Stability:    Stable 3 months frozen.
Ref Lab/Code:    ARUP 2010102
  Method:    Transcription Mediated Ampification
Note:    Do not use for initial prostate cancer screening. Preferred test is total prostate specific antigen (PSA) in conjunction with digital rectal exam. The PCA3 test may be useful, in conjunction with other patient information, to aid in the decision for repeat biopsy in men 50 years of age or older who have had one or more previous negative prostate biopsies and for whom a repeat biopsy would be recommended by a urologist based on current standard of care.