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BCR-ABL1 Mutation Analysis for Tyrosine Kinase Inhibitor Resistance by Next Generation Sequencing

Mnemonic:    [Unlist Lab]
Name:    BCR-ABL1 Mutation Analysis for Tyrosine Kinase Inhibitor Resistance by Next Generation Sequencing
Specimen:    5 mL whole blood from a Lavender top tube. or 3 mL bone marrow.

Include information regarding any current kinase inhibitor treatment the patient may be receiving.

Clotted samples are unacceptable.

Ambient/frozen samples are unacceptable.

Plasma and serum are unacceptable.
Minimum Spec:    1 mL
Transport Temp:    Refrigerated
Spec Stability:    Stable 48 hours refrigerated.
Ref Lab/Code:    ARUP 2008420
  Method:    Massive Parallel Sequencing
Note:    Order only for patients with an established diagnosis of a BCR-ABL1 positive leukemia. This test is used to determine if a mutation is present that would interfere with response to TKI therapy in Philadelphia chromosome positive (Ph+) lymphoblastic leukemia or chronic myelogenous leukemia (CML). The test detects all common mutations, including T315I. For initial BCR-ABL1 testing, refer to the reflex test (2005010).