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Metanephrines Fractionated by HPLC-MS/MS, Urine

Mnemonic:    [U Metaneph]
Name:    Metanephrines Fractionated by HPLC-MS/MS, Urine
Specimen:    4 mL aliquot from a 24 hour or random urine collection. Recommended Patient Preparation: Abstain from medications for 72 hours prior to collection. Consult with your physician.
Minimum Spec:    1.5 mL
Transport Temp:    Refrigerated
Spec Stability:    Stable up to 2 weeks refrigerated.
Ref Lab/Code:    ARUP 2007996
  Method:    HPLC/Tandem Mass Spectrometry
Note:    A metanephrine-to-creatinine ratio will be reported when:
1) the patient is under 18 years or
2) the urine collection is random or other than 24 hours or 3) the urine volume is less than 400 mL/24 hours.
Processing Info:    Record the sample total volume and collection time interval on the transport tube. Have a tech verify the SR TIME and SR VOLUME in the computer before transmitting the packing list.

Adequate refrigeration is the most important aspect of specimen preservation. Stability can be enhanced at pH 2 - 4. A pH of < 2 may cause assay interference.

Collection instructions for a 24 hour urine sample