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Neuronal Nuclear Antibodies (Hu, Ri, Yo), IgG by Western Blot

Mnemonic:    [UNLIST LAB]
Name:    Neuronal Nuclear Antibodies (Hu, Ri, Yo), IgG by Western Blot
Specimen:    1 mL serum from a Red SST or Red top tube. Separate serum from cells ASAP.
Minimum Spec:    0.5 mL
Transport Temp:    FREEZE
Spec Stability:    Stable up to 2 weeks refrigerated.
Ref Lab/Code:    ARUP 2007963
  Method:    Western blot
Note:    ANNA-1 = anti-Hu
ANNA-2 = anti-Ri
PCCA or PCA-1 = anti-Yo or anti-Purkinje cell cytoplasmic antibody

PCCA/ANNA antibodies are screened by IFA. If the IFA screen is positive at 1:10, then a specific titer (PCCA or ANNA) and immunoblot will be added.

Interpretive Data: This test detects IgG antineuronal antibodies to Hu, Ri, and Yo antigens. Only the antibodies detected are reported in the result field.