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Celiac Disease Reflex Cascade

Mnemonic:    [Cel Casc]
Name:    Celiac Disease Reflex Cascade
Specimen:    2 mL serum from a Red SST or Red top tube. Plasma, hemolyzed, grossly lipemic or contaminated samples are unacceptable.
Minimum Spec:    1 mL
Transport Temp:    Refrigerated
Spec Stability:    Stable 7 days refrigerated.
Ref Lab/Code:    ARUP 2008114
  Method:    Multiple Methods
Note:    The Celiac Disease Reflexive Cascade begins with Immunoglobulin A. Depending on findings, one or more reflexive tests may be required in order to provide a clinical interpretation.

Tests added may include Tissue Transglutaminase Antibody, IgA; Tissue Transglutaminase Antibody, IgG; Endomysial Antibody, IgA by IFA; Deamidated Gliadin Peptide (DGP) Antibody, IgA; Deamidated Gliadin Peptide (DGP) Antibody, IgG; and/or Celiac Disease Dual Antigen Screen.

Refer to the Celiac Testing Algorithm found at http://www.arupconsult.com/Algorithms/CeliacDz.pdf.