Pha= rmacokinetics [PHARMACO]
General Information
The pharmacokinetics label is used to alert the phle= botomy staff that a drug level is scheduled to be drawn and will require special coordination of the sample collection timing with the drug administration timing. This will require communication with nursing personnel to ascertain= the exact drug administration time. The pharmacokinetics label is associated wi= th: Gentamicin, Tobramycin, Amikacin and Vancomycin levels in the PathNet Laboratory Information System.
Results of these determinations are used as the basi= s for pharmacokinetic calculations to adjust future drug doses. Accurate timing of these sample collections is critical to the accuracy of the pharmacokinetic calculation.
These drug level orders are generally entered by the= staff pharmacist with proposed collection times indicated in the order comments. =
Pre-dose
These samples are collected before an intraveno= us drug is administered. They should indicate “Pre-dose” and the proposed time of drug administration in the order comments. These orders are generally scheduled ½ hour before the next drug administration and should be ordered with a Timed priority (TM) to avoid netting of the order = to a different schedule time. These samples may be drawn anytime within approximately ½ hour prior to the drug administration and MUST BE BE= FORE drug administration.
Phlebotomists must:
· Check the comments on the order to be aware = of scheduled drug administration time.
· Check before collecting these samples to con= firm that the drug administration has not started.
· If drug administration has been started, do = not collect the sample. Contact the pharmacist immediately at x2325 for instructions.
· Indicate the exact sample collection = time on the sample label (large label) in the usual manner.
Post-dose
These samples are collected after an intravenous dru= g is administered. They should indicate “Post-dose” and the proposed time of drug administration in the order comments. These orders are general= ly scheduled ½ hour AFTER THE COMPLETION of drug administration and should be ordered with a Timed priority (TM) to avoid netting of the order to a diffe= rent schedule time. These samples should be drawn ½ hour after to the drug administration and NEVER DURING DRUG administration.
Phlebotomists must:
· Check the comments on the order to be aware = of scheduled drug administration time.
· Check before collecting these samples to con= firm the time of completion of the drug administration.
· If drug administration has not been started,= do not collect the sample. Contact the pharmacist immediately at x2325 for instructions.
· If drug administration is later than the proposed/scheduled time, reschedule the post-dose collection for ½ a= fter the anticipated completion of the drug administration.
· Collect samples ½ hour after the COMPLETION OF drug administration.
Interval Timing
Occasionally, drug levels are drawn a number of hours after administration of the drug. The is known as “Interval Timing= 221;. This only applies to aminoglycosides. These orders should indicate “I= nterval Timing” in the order comments. These orders are scheduled for an exact time with a Timed priority (TM) by the pharmacist and should be collected within ONE hour of the scheduled time.
Phlebotomists must:
· Check the comments on the order to be aware = of scheduled drug administration time.
· Collect the sample within ONE hour of the scheduled time and indicate the exact collection time on the sample label (large label).
Example of Label
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